Outreach

Gioele La Manno was included in Clarivate’s 2025 Highly Cited Researchers list for the second consecutive year, recognizing his continued impact in single-cell transcriptomics and brain development research.

We released the first comprehensive lipidomic atlas of the adult mouse brain on bioRxiv. Using MALDI mass spectrometry imaging, we mapped 172 membrane lipids across 109 sections and identified 539 spatially coherent biochemical domains we call lipizones.

The lab has been awarded an ERC Starting Grant (1.5M euros, 2026-2031) for the project MOVIOLA: Cell decision capture and control via joint Raman live and omics profiling, to understand molecular determinants of neural cell fate decisions.

By combining imaging mass spectrometry and a new computational framework called uMAIA, we tracked more than 100 types of lipids in space and time in the developing zebrafish embryo, revealing how lipids form highly organized patterns that correspond to anatomical structures. Published in Nature Methods.

Our collaborative work on Spotiflow, a deep learning method for subpixel-accurate spot detection in fluorescence microscopy, has been published in Nature Methods. The method achieves state-of-the-art performance while being robust to different noise conditions.

Gioele La Manno was included in Clarivate’s 2024 Highly Cited Researchers list, recognizing his innovative work in single-cell transcriptomics and brain development. At 34 years old, he is one of the youngest researchers on the list.

VeloCycle, our Bayesian model of RNA velocity for the cell cycle, has been published in Nature Methods. The method enables formal statistical testing of gene expression dynamics and identified developmental modulations of cell cycle speed.

The lab has been awarded an SNSF Starting Grant to demystify the role of lipids in the brain’s developmental blueprint, probing into uncharted functions of lipid metabolism to uncover how diverse lipid species impact neural cell formation and specialization.

The Board of the Swiss Federal Institutes of Technology has announced the appointment of professors at EPFL, including our group leader Gioele!

Who is science made by? And how do you become a researcher? Gioele La Manno describes the journey to become a scientist, sharing a point of view on many misconception of the figure of the scientist