Outreach

Using a combination of sequencing techniques and mathematical methods, our lab has traced the genetic programs that direct the development of each cell in the brain. This molecular map help understanding how the brain develops and provide insights into a range of brain disorders. Nature paper here

Our lab in collaboration with the Lanner lab has tested and confirmed a protocol for growing human embryonic stem cells into retina cells to treat eye diseases such as age-related macular degeneration. Stem Cell Reports paper here

Using single-cell lipidomics our lab and the lab of Giovanni D’Angelo discovered the existence of lipotypes, cell states characterized by their lipid composition. We describe how lipid composition can play a key role in determining functional transitions. Science paper here

Our lab has developed an algorithm that can work out the spatial pattern of gene expression inside the body without the need for microscopes and complicated equipment used currently. Nature Biotech paper here

The lab is the recipient of one of the 79 grants awarded this year across all scientific disciplines. I am really honored by this recognition. This SNF grant will allow us to study, using cutting-edge technologies, the complex cellular dynamics of progenitor cells during brain development.

The Chan Zuckerberg Initiative (CZI) has awarded a grant to the lab of Gioele La Manno, together with the Karolinska Institute and The University of Edinburgh. The collaborative research aims at new therapies for multiple sclerosis, and will be part of the Human Cell Atlas project.

I have been appointed the first Scholar of the EPFL Life Sciences Early Independence Research program (ELSIR), a revolutionary fellowship that gives talented PhD graduates the kind of research independence they could usually only get much later in their career.

Researchers at Karolinska Institutet and Harvard Medical School report in the journal Nature that they have developed a technique for capturing dynamic processes in individual cells. Apart from studying disease processes, the method can be used to observe in detail how specialised cells are formed during embryonic development.

Two research teams at Karolinska Institutet have identified the dopamine-producing cells in the midbrain of mice and humans. They have also developed a method of assessing the quality of in-vitro cultured dopamine-producing cells, which can be of great benefit to research on Parkinson’s disease. The results are published in the academic journal Cell.

The sympathetic nerve system has long been thought to respond the same regardless of the physical or emotional stimulus triggering it. However, in a new study from Karolinska Institutet published in the journal Nature Neuroscience, scientists show that the system comprises different neurons that regulate specific physiological functions, such as erectile muscle control.