Midbrain Dopaminergic Neuron Development is Regulated by Two Molecularly Distinct Subtypes of Radial Glia Cells

Asgrímsdóttir ES, Fusar Bassini L, Rivetti di Val Cervo P, Gyllborg D, Puigsasllosas Pastor C, Lee K, Grigsby C, Islam S, Lönneberg P, Villaescusa C, Saltó C, Linnarsson S, Castelo-Branco G, La Manno G, Toledo EM, Arenas E

Abstract

Midbrain dopaminergic neuron development is regulated by two molecularly distinct subtypes of radial glia cells. This study reveals the heterogeneity of radial glia in the developing midbrain and their distinct roles in controlling dopaminergic neuron generation.