cell fate

Using a combination of sequencing techniques and mathematical methods, our lab has traced the genetic programs that direct the development of each cell in the brain. This molecular map help understanding how the brain develops and provide insights into a range of brain disorders. Nature paper here

Our lab in collaboration with the Lanner lab has tested and confirmed a protocol for growing human embryonic stem cells into retina cells to treat eye diseases such as age-related macular degeneration. Stem Cell Reports paper here

Using single-cell lipidomics our lab and the lab of Giovanni D’Angelo discovered the existence of lipotypes, cell states characterized by their lipid composition. We describe how lipid composition can play a key role in determining functional transitions. Science paper here