lipidomics

We released the first comprehensive lipidomic atlas of the adult mouse brain on bioRxiv. Using MALDI mass spectrometry imaging, we mapped 172 membrane lipids across 109 sections and identified 539 spatially coherent biochemical domains we call lipizones.

By combining imaging mass spectrometry and a new computational framework called uMAIA, we tracked more than 100 types of lipids in space and time in the developing zebrafish embryo, revealing how lipids form highly organized patterns that correspond to anatomical structures. Published in Nature Methods.

Using single-cell lipidomics our lab and the lab of Giovanni D’Angelo discovered the existence of lipotypes, cell states characterized by their lipid composition. We describe how lipid composition can play a key role in determining functional transitions. Science paper here