Specialized signaling centers direct cell fate and spatial organization in a limb organoid model

Skoufa E, Zhong J, Kahre O, Hu K, Tsissios G, Carrau L, Herrera A, Dominguez Mantes A, Castilla-Ibeas A, Jang H, Weigert M, La Manno G, Lutolf M, Ros M, Aztekin C

Abstract

This study demonstrates how specialized signaling centers direct cell fate and spatial organization in a limb organoid model, providing insights into limb development and regeneration mechanisms.