development

Using a combination of sequencing techniques and mathematical methods, our lab has traced the genetic programs that direct the development of each cell in the brain. This molecular map help understanding how the brain develops and provide insights into a range of brain disorders. Nature paper here

It is super exciting to release this resource we have been working so long for: an atlas of all the cell states appearing in mouse brain development, between gastrulation and birth!

Researchers at Karolinska Institutet and Harvard Medical School report in the journal Nature that they have developed a technique for capturing dynamic processes in individual cells. Apart from studying disease processes, the method can be used to observe in detail how specialised cells are formed during embryonic development.

Two research teams at Karolinska Institutet have identified the dopamine-producing cells in the midbrain of mice and humans. They have also developed a method of assessing the quality of in-vitro cultured dopamine-producing cells, which can be of great benefit to research on Parkinson’s disease. The results are published in the academic journal Cell.

The sympathetic nerve system has long been thought to respond the same regardless of the physical or emotional stimulus triggering it. However, in a new study from Karolinska Institutet published in the journal Nature Neuroscience, scientists show that the system comprises different neurons that regulate specific physiological functions, such as erectile muscle control.