Luca Fusar Bassini and Alessandro Valente join the lab for a PhD. Luca is a Biologist with a keen interest in developing computational methods to obtain unprecedented biological insight, Alessandro is Biotechnologist with experience in stem cell engineering in organoids. They are both going to work on the lipidome-transcriptome axis in neurulation. Welcome Luca and Alessandro!
We wrote a piece with Giovanni D’Angelo titled “The lipotype hypothesis” on Nature Reviews Molecular Cell Biology! Considering recent evidence on lipid-cell response to interaction cues, we proposed that cell variability in lipid composition assists the divergence of differentiation trajectories, leading to the establishment of several cell identities.
It is super exciting to release this resource we have been working so long for: an atlas of all the cell states appearing in mouse brain development, between gastrulation and birth!
A new project granted! We will work towards “A Probabilistic Framework for RNA Velocity Statistical Tests Using Pyro” together with Luca Pinello lab in Boston and Eli Bingham, the creator of Pyro. more info here
Using single-cell lipidomics our lab and the lab of Giovanni D’Angelo discovered the existence of lipotypes. Cell’s lipid composition can play a key role in determining what that cell will become. Science paper here
Our work on Tomographical reconstruction of sequencing based technologies is now on the biorxiv. Enjoy!
Dimitri Lallement joins the lab for a Masters thesis project. He is enrolled in the Computer Science Engineering program, ENSIMAG at Grenoble and doing a exchange with EPFL. He has studied his Bachelor at the University of Bordeaux and studied as Data Scientist Junior at CNES. He wants to face challenging research problem and explore new methods that can help the interpretation of single-cell RNAseq datasets. Welcome Dimitri!
Halima Schede joins the lab for a Masters project. She is enrolled in the Bioengineering program and has studied in biology and mathematics at McGill. With her passion for machine learning and neural networks and her knowledge of anatomy and genetics she will turn a bunch of omics data in useful insights of the molecular anatomy of the brain. Welcome Halima!
Anurag Ranjak joins the lab for a Masters project. Anurag is a Chemical Engineer with industry experience in software engineering. He will adventure in spatial transcriptpomics and image reconstruction.He recently “converted” to biology and enrolled in EPFL Masters in Life Sciences. Welcome Anurag!
Our work on RNA velocity, the time derivative of gene expression, is now out in Nature. A lot of interesting new evidence and analysis added to the initial bioarxiv preprint. We put great attention to feature possibilities and the limits of the estimation approach. velocyto software is mature and ready to use. Enjoy!